This course will focus on the co-evolution (still in progress) of the protective mechanisms of organisms against a variety of pathogens and the pathogens’ evasion mechanisms of immune surveillance. Topics will include the nature of pathogens, mucosal surfaces as the first barrier to pathogens in vertebrates, evolution of the immune response to pathogens in the plant and animal kingdom, co-evolution of evasion mechanisms in viruses, bacteria, and protozoa to bypass or neutralize the immune response, diagnosis and treatment of microbial disease. Students will research a pathogen of their choice throughout the semester and will present their findings in poster or web page format.